For all of the controversy, there’s a lot of misinformation, myth, and misunderstanding. Let’s clear some of that up.

Second, it works on many different physiological systems. Like many molecules, it does one thing in one part of the body, and something else in another part of the body. For example, in the brain, caffeine stimulate the release of epinephrine (adrenaline) from specific cells in the brain. This leads to alertness, stimulation, and other things. It also competes with adenosine in the brain. Think of adenosine as the brains sleepy molecule. As adenosine builds up, we tend to drift into a state of needing rest or sleep. Caffeine competes with the sleepy molecule and in most cases it wins. When it wins, you are pushed into a state of alertness and motivation.

Phosphodiesterase is a complex molecular machine that breaks down one of our bodies main stimulating molecules called cyclic AMP (cAMP for short). cAMP stimulated the release of epinephrine among many other things, and it gets broken down by phosphodiesterase. It’s like cAMP is building a beautiful fire and burning those calories from the donut you ate, and
phosphodiesterase comes along and pours water over the fire—stupid phosphodiesterase. Caffeine comes along and blocks phosphodiesterase and allows that fire to KEEP BURNING BABY! Maybe a little dramatic, but you get it.
These are some of the important, certainly not all, of the effects of this wonder molecule.
It can interrupt sleep so use it in the morning and avoid in the afternoon. It also causes sensitivity to dopamine which is actually awesome but worth its own conversation.

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-Hugs and kisses.